janumet xr



What is Janumet (sitagliptin/metformin)?

Janumet contains a mixture of sitagliptin and metformin medicine. Metformin and sitagliptin are oral diabetes medications that help control blood sugar levels in people with type 2 diabetes mellitus.

Generic Name: sitagliptin metformin HCl
Brand Name: Janumet
Drug class:DPP-4 inhibitor / Biguanide

Important Information About JANUMET

  • JANUMET (JAN-you-met) tablets contain 2 prescription drugs: sitagliptin (JANUVIA®) and metformin.
  • JANUMET or JANUMET XR can be used to lower blood sugar in adults with type 2 diabetes along with diet and exercise.
  • Janumet or Janumet XR is not intended for use in patients with type 1 diabetes.


This combination drug Janumet (sitagliptin/metformin) is used along with an appropriate diet and exercise program and is probably taken along with other medications to control high blood sugar. Doctors recommend using this medicine for patients with type 2 diabetes.

Limitations of Use

It is not for the treatment of type 1 diabetes. It was not studied in patients with a history of pancreatitis.

Sitagliptin -Sitagliptin works by increasing the level of natural substances called incretins. After meals, these incretins help control blood sugar by increasing insulin release in your body. It also helps in reducing the production and absorption of glucose (sugars) by the liver and intestines.

Metformin - Metformin works to help maintain your body's proper response to the insulin you naturally produce. It also reduces the amount of sugar produced by your liver and reduces the absorption of glucose by your stomach/intestines. Controlling high blood sugar helps prevent kidney damage, blindness, loss of organs, nerve problems, and sexual function problems.

How to use Janumet

Read the medication guidelines given by your pharmacist before you start using Janumet. If you have any questions about this medicine, ask your doctor or pharmacist.

Take this medicine by mouth as directed by your doctor, usually with food twice a day. Take plenty of fluids while taking this medicine, unless directed by your doctor and you cannot use this medicine without the doctor's advice.

Regularly check your blood sugar as directed by your doctor. And share the results with your doctor. Tell your doctor if your blood sugar measurement is too high or too low. Accordingly, your doctor will try to regularize your dose/treatment.

Before taking this medicine

If you are allergic to Janumet (metformin or sitagliptin), or if you have severe kidney disease, So first of all, to make sure that Janumet is safe for you or not, tell your doctor if you have any disease ever given below.

  • Kidney disease (before and after taking this medicine you can check your kidney function)
  • Liver disease
  • heart disease
  • Pancreatitis
  • High triglycerides (a type of blood fat);
  • Gallstones
  • Alcoholism

Adult Dosage

Take it with food. Currently not treated with metformin:

  • Janumet 50mg / 500mg- Dose of 50 mg sitagliptin / 500 mg
  • Janumet 50 mg / 1000mg - containing a dose of 50 mg sitagliptin / 1000 mg metformin.
  • Janumet 100 mg / 2000mg- All: Maximum 100 mg sitagliptin / 2000 mg metformin dose per day.

Kidney loss (eGFR 30– <45mL / min / 1.73m2): Not recommended

Children Dosage

Not established for people under 18 years.

JANUMET Contraindications in patients with

Severe renal impairment (eGFR <30mL/min/1.73m2). Acute or chronic metabolic acidosis, including diabetic.

Generic Drug Availability


See also



You should not use Janumet if you have diabetic ketoacidosis or severe kidney disease. You should contact your doctor for treatment with insulin.
Janumet can cause a serious condition called lactic acidosis.

If you also have mild symptoms such as muscle pain or weakness, trouble breathing, numbness or chills in your hands and feet, abdominal pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak. Then get emergency medical help. Because lactic acidosis can also result in death, hypothermia, hypotension, and obstructive bradycardias.

Janumet can also cause a serious condition called pancreatitis. If you have severe abdominal pain with or without vomiting, contact your doctor immediately.